Factor MW Plasma concentration Synthesis Half-life in vivo
Contact phase Factor XII 80 30 µg/ml Liver 2-3 days
Factor XI 160 homodimer 3-7 µg/ml Liver 2-3 days
HMW Kininogen 85 30-50 µg/ml Liver 5-6 days
Prekallikrein 120 60-80 µg/ml Liver 1-2 day(s)
Vitamin K dependent proteins Factor II or Prothrombin 72 100 µg/ml Liver 1-2 day(s)
Factor VII 50 0,3-0,5 µg/ml Liver 4-6 hours
Factor IX 55 4-5 µg/ml Liver 24 hours
Factor X 58 8-12 µg/ml Liver 1-2 day(s)
Protein C 62 4-5 µg/ml Liver 4-6 hours
Protein S 69 10 µg/ml (free), 25 µg/ml (total) Liver 1-2 day(s)
Protein Z 62 2-4 µg/ml Liver 2-3 days
Inhibitors AT III 58 150 µg/ml Liver 2-3 days
α2-Macroglobuline 725 2-5  mg/ml Liver, Endothelial cells 2-3 days
Heparin Co-II 66 90  µg/ml Liver 2-3 days
Protein C inhib. (PAI-3) 57 5 µg/ml Liver 1 day
TFPI 33 8-15  ng/ml (Free) 60-100 ng/ml (total) Endothelial cells

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Protein Z inhib. (ZPI) 72 3-7  µg/ml Liver 2-3 days
Cofactors Factor VII 330 10  µg/ml Liver, Megacaryocytes 12 hours
Factor VIII:C 265 0.1 µg/ml Liver 12 hours
Thrombomodulin 60 Expressed on Endothelial cells Endothelial cells
Fibrinolysis C1-INH 106 180 µg/ml Liver 1-2 day(s)
Plasminogen 90 200 µg/ml Liver 2-3 days
HRGP 67 100 µg/ml Liver 3 days
α2-AP 70 70 µg/ml Hepatocytes 60 hours
tPA 68 < 10 ng/ml Endothelial cells 5 min
uPA 55 < 5 ng/ml Kidney 8 min
PAI-1 50 < 30 ng/ml Endothelial cells, Liver, Megacaryocytes 5 min
PAI-2 47 < 10 ng/ml Placenta, Leukocytes, Macrophages 120 min
TAFI 60 2.5 µg/ml Liver
Others C4b-BP 590 250 µg/ml 2-3 days
vWF 500-2000 (sub-units of 260) 8-12 µg/ml Endothelial cells, Liver, Megacaryocytes 12 hours
Tissue Factor 45 Extra vascular Many non vascular cells, Monocytes, Endothelial cells

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Fibrinogen 340 2-4 mg/ml Liver 2-3 days
β2G1 50 200 µg/ml Liver
Factor XIII 320 (A2B2 Complex) 10-15 µg/ml Liver 3-4 days